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YEAR-1 Course management

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Ms. Mona suffers from motion sickness. Her physician prescribes her diphenhydarmine.

Which is the most likely mechanism of action of this drug in her condition?

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A 45-year-old man presents with chronic diarrhea, weight loss, and fatigue. His laboratory tests show microcytic anemia, low serum iron, and low ferritin. Duodenal biopsy reveals villous atrophy and increased intraepithelial lymphocytes.

Which is the most likely diagnosis of this case?

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A hypertensive patient is being treated with a diuretic. He develops gout as a side effect of the diuretic.

Which is the most likely diuretic causing this side effect?

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An awareness campaign is carried out addressing carcinoma of the stomach. The discussion has led to the predisposing factors and gastric site distribution.

Which is the most likely statistically frequent site showing gastric malignancy?

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A 24 year old man presents with symptoms of shortness of breath, weakness and fatigue. His hemoglobin level is 7g/dl. Red blood cell isolated from the patient shows an abnormally low-level of lactate.

A deficiency of which enzyme would be the most likely cause for this patient’s anemia?

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A 30-year-old researcher has colic & diarrhea. He also has headache and insomnia. His tongue is abnormally red. He is in France performing his research studies. He reports that he frequently goes in a fishing trip in the lakes. He eats some of caught fish lightly grilled on charcoal while still on the boat. Lately, he has itching at the anal area and passes a tape like structure.

What is the most likely pathogen responsible for this condition?

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A new diagnostic test provides fast, simple, and cheap detection of HCV infection. In a sample of 500 people, only 35 are confirmed to have HCV infection using the gold standard PCR test.

Using the following results, calculate the sensitivity of the test.

 

Condition (HCV infection)

YES

NO

Total

New diagnostic test results

+ve

30

15

45

-ve

5

450

455

Total

35

465

500

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A 57 year old man is brought to the ED with difficult swallowing. Imaging reveals injury of the swallowing afferent nerve fibers.

Which cranial nerve is most likely injured?

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An 8-year-old girl has early puberty and short stature. She is treated with an allosteric modifier. Which is the most likely mechanism of allosteric regulation in this case?

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A 10-year old boy has muscle weakness. Genetic testing reveals a mutation in Carnitine acyl transferase II (CAT II) gene and he is diagnosed with CAT II deficiency. Which single product arises from the reaction catalyzed by this enzyme?

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