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Phase 3 Medicine 2026

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A 25-year-old woman, 50 kg, presents with nausea, vomiting and

abdominal pain for the last few hours. She has dental pain and has been taking 1g paracetamol orally every 4 hours for the last 3 days. 

On examination of her abdomen, you note it is soft, mildly tender in right upper quadrant. Paracetamol level is 35 mg/L, ALT 800 IU/L. HR 90 bpm, BP 100/70 mm Hg, temp 37.4°C.  

Nomogram

What is the most appropriate treatment for this patient?

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With

the patients above, which of the following is the most likely contaminant in the

herbal tea?

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A 39-year-old man and his wife are brought in by ambulance

to the ED due to disorientation and agitation. They were found by neighbours,

wandering in their street.  The ambulance

team says they seemed to have drunk a herbal tea that morning.

On examination, they are disoriented with tachycardia,

dilated pupils, dry mucous membranes, dry skin and urinary retention.

Question:

What toxidrome does the patient demonstrate?

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A 35-year-old male is brought in by ambulance with an overdose of

paracetamol. He was found by neighbours alone in his unit. He had written a

suicide note that says he took 50 tablets of 500mg, dated 3 days ago.

On arrival, he is jaundiced. HR 105, BP 105/90, RR 24, Temp

36.1. He is unable to follow commands and is disorientated to time place and

person.

His pathology findings are:

  • Bilirubin 82umol/L (1-20)
  • ALT 3890 U/L (5-40)
  • AST 7257 U/L (5-30)
  • Alkaline phosphatase 178 U/L (30-110)
  • Creatinine 0.30 mmol/L (0.60-0.11)
  • INR 6.9 (< 1.5)
  • Paracetamol level is 22 mg/L

Paracetamol treatment nomogram

Which

of the following is the most immediate management in the ED?

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A 45-year-old man is brought in by his wife. He accidentally

ingested unknown concentration of bleach thinking it was a sports drink. His airway is

patent, he has no stridor, there is no erythema or swelling in the mouth. He

complained of pain on swallowing and finds it hard to drink fluid. His HR 80 bpm, BP 120/80 mm hg, RR 14 bpm and

SaO2 98% room air.

Question:

Which of the following management

steps is the most appropriate in the ED?

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A 20 year-old patient presents with an overdose of paracetamol.

What are the important factors that need to be considered in order to make a proper risk assessment for the paracetamol poisoning? (more than one answer is correct)

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A 70 kg 45-year-old man presents 4 hours following an ingestion of 20x5mg oxycodone. In your ED, he is drowsy but rousable, HR 70 bpm, BP 110/70, RR 6/min, O2 sat 90% RA, GCS 8 (E1V2M5).

What is the most appropriate treatment for this patient?

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A 60kg 19-year-old

university student presents after a weekend of partying and taking

methamphetamine with friends. She complains of feeling anxious with palpitation

and chest pain. In your ED, she looks slightly agitated. Her RR at rest is 24/min, HR

110 bpm, BP 140/90mmHg and her SaO2 is 95% at rest, temp 37°C. ECG shows sinus tachycardia.

What would be the most appropriate management for this patient?

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For the same patient above, the paracetamol level at 4h is 200 mg/L. What is the next most appropriate step?

Paracetamol Treatment Nomogram (Rumack-Matthew Nomogram)

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A 45

kg 17-year-old girl presents 1.5 hours following ingestion of 30 x 500 mg of

paracetamol which she washed down with 5 glasses of wine. She appears

well and is cooperative.

Should this patient receive decontamination for her paracetamol poisoning? Please choose the most appropriate answer.
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