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BCH2011 - Structure and function of cellular biomolecules - S1 2025

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It is possible for a DNA duplex to have how many different reading frames?

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The sequence below represents the coding DNA strand of the start of a gene, including part of the 5' untranslated region.

(5')...ACCGAAGGAGGTCGCAGCAATGAAACGATTTCGGCACA...(3')

In studying disease variants, a nucleotide mutation of T→C was detected in the third base of the fourth codon. What effect would this mutation have? 

(When considering your answer, assume standard initiation of translation is numbered as codon 1.)

Image failed to load: Codons AAs and names

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Consider the following coding strand DNA sequence, written 5'-to-3':

AATATCATTTGTGAA

If this sequence were to be directly translated from the first base, what is the amino acid sequence (in single letter code) that would arise?

(Your answer should only include single-letter amino acids. Do not include spaces or other non-amino acid characters.)

Image failed to load: CodonAAs

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The sequence below represents the coding DNA strand of the start of a gene, including part of the 5' untranslated region.

(5')...ACCGAAGGAGGTCGCAGCAATGAAACGATTTCGGCACA...(3')

In studying disease variants, a nucleotide mutation of T→C was detected in the third base of the fourth codon. What effect would this mutation have? 

(When considering your answer, assume standard initiation of translation is numbered as codon 1.)

Image failed to load: Codons AAs and names

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Using your knowledge of the genetic code and the image below, which ONE of the following amino acid replacements can be caused by a single nucleotide change?

Image failed to load: Codons

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Consider the following tripeptide:

Asn-Ile-Tyr

In the box below, enter a minimal DNA sequence (coding strand), written 5'-to-3', that could give rise to this peptide. Do not include an initiating codon at the start. Please just enter in the codons for the given peptide above.

(You should only include nucleotides in your answer, e.g. AAAA... Do not include 5' or 3', spaces, or any other non-nucleotide characters.)

Image failed to load: Codons

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Concerning the genetic code, which ONE statement is true?

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Consider the following coding strand DNA sequence, written 5'-to-3':

ATTGACGAGGCGCTA

If this sequence were to be directly translated from the first base, what is the amino acid sequence (in single letter code) that would arise?

(Your answer should only include single-letter amino acids. Do not include spaces or other non-amino acid characters.)

Image failed to load: CodonAAs

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The image below shows the three main sites -- E, P and A -- of the ribosome involved in the process of translation.

Image failed to load: Ribosome sites

A new inhibitor of translation has been found that occupies the "A" site.

What specific effect would this have on translation?

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Concerning the central dogma of molecular biology, which ONE of the following statements is true?

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