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DEV3011 - Experimental developmental biology and disease modelling - S1 2026

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Consider the genetic pedigree tree below for a genetic disorder.

 What is the most likely mode of inheritance?
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Consider the genetic pedigree tree below for a genetic disorder.

 What is the most likely mode of inheritance?
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Consider the image

below of a section through the developing neural tube

If I conducted

in

situ

hybridisation on this neural tube, which of the following would I

see?

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Consider the limb bud below, in which a chicken embryo has a gene mutation that blocks proper formation of the structure marked by X.

What is the first and most obvious defect that

would occur in the limb bud if tissue X failed to form?

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What technique could

be used at a population level to identify genetic variants linked to congenital heart disease?

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How does a testis form at the genetic level?
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What tissue plays a key role in the final identity of digits, downstream of Sonic Hedgehog signaling?

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In developmental biology, what term is given to the phenomenon whereby one gene can affect more than one trait?

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A mouse embryo has a mutation that disrupts specification of the sclerotome. What direct effect might this have?

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What is a feature of cadherins? Chose the correct answer below.

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