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DEV3011 - Experimental developmental biology and disease modelling - S1 2026
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Two morphogens are produced along the anterior-posterior axis of the Drosophila embryo.
Morphogen 1 is expressed most highly at the anterior pole, tapering with distance from its source.
Morphogen 2 is expressed highly at the posterior pole, also tapering with distance from its source.
Expression of Gene 3 is stimulated only by intermediate levels of morphogen 1.
Expression of Gene 4 is inhibited by any expression of gene 3 and morphogen 2.
Expression of Gene 5 is stimulated only by intermediate and high levels of morphogen 1.
Expression of morphogen 2 is inhibited by any level of gene 5 expression.
In the figure above, the arrow denotes the expression of which gene or morphogen?
A researcher is using a dominant modifier screen to study eye size in Drosophila . The images below are of adult eyes with four different phenotypes in random order: wild type, sensitised, sensitised + enhancer mutant and sensitised + suppressor mutant.
Which image shows the sensitised + suppressor mutant eye?
in mouse. The mutation was generated on a genetic background represented by the black regions of DNA. This was crossed to a wildtype strain represented by white regions of DNA.
Define the region of the chromosome pair (A, B, C or D) that contains the mutation.
You decide to use transcript microarray to analyse development of the chicken embryo limb bud.
What does this method achieve?