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DEV3011 - Experimental developmental biology and disease modelling - S1 2026

DEV3011 - Experimental developmental biology and disease modelling - S1 2026

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In the process of convergence extension, where is PCP signalling active within cells?

Apical and basal borders of the cells

Anterior and posterior edges of the cells

Medial and lateral edges of the cells

Dorsal and ventral surfaces of the cells

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A mouse embryo has a mutation that specifically disrupts formation of the myotome. What direct effect might this have?

Disturbed trunk and limb muscle development.

Failure of somite formation.

Malformed cartilage.

Lack of tendons.

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What does a high LOD

score mean?

A genetic variant is disease-causing.

A particular gene in the genome is loaded with mutations.

Two loci are located close together in the genome.

Two loci are located a long distance apart in the genome.

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In the chicken embryo,

a researcher has added extra AER to the forelimb bud.

Which result might

they expect?

Choose the best option below.

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What have researcher dubbed “iBlastoids”?

Stem-cell derived blastocysts

An in vivo model of human blastocysts

Cells grown in culture that express Oct4

Blastoderms designed by AI

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Consider the family pedigree below, in which a monogenic autosomal congenital abnormality is denoted by shaded squares/circles.

Based on the pedigree shown, what term describes the abnormality?

Y chromosome-linked

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You conducted immunhistochemistry for the detection of Sry protein in the mouse embryonic urogenital system. What is the best negative control?

embryonic mouse testis

embryonic mouse ovary

tissue sections with primary antibody

embryonic somites ectopically expressing Sry

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A researcher adds TGFβ3-soaked bead to the embryonic chicken craniofacial region. What effect would this have on palatal formation?

It would induce cleft palate

Mesenchyme to epithelial conversion

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What is the initiating factor responsible for Treacher-Collins syndrome?

Failure of neural crest cell migration.

Over-proliferation of cells in the neural epithelium.

Increased apoptosis of neural crest progenitors.

Migration of neural crest cells from the ventral and as well as dorsal neural plate border.

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The image below shows anterior boundaries of Hox gene expression in the mouse embryo.

Name the gene expression domain denoted by the arrow.

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