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DEV3011 - Experimental developmental biology and disease modelling - S1 2026

DEV3011 - Experimental developmental biology and disease modelling - S1 2026

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The image below shows anterior boundaries of Hox gene expression in the mouse embryo.

Name the gene expression domain denoted by the arrow.

Hoxd13

Hoxb2

Hoxd7

100%

Hoxa1

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Opposing gradients of which factors regulate formation of the end of the spinal cord along the anterior-posterior axis?

RA and Wnt/FGF

100%

Mesenchymal cells and epithelial progenitors.

RA and SHH

SHH and TGF-Beta.

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If a moderate level of Shh expression was expressed throughout the axis of the spinal cord, what would you expect to happen?

Transcription factors that normally inhibit expression would activate expression instead

Motor neurons would develop across the dorsal-ventral axis, and fewer interneurons

100%

There would be an expansion of interneurons, and inhibition of motor neuron development

There would be a reduction of BMP signalling from the notochord and floor plate

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The image below shows anterior boundaries of Hox gene expression in the mouse embryo.

Name the gene expression domain denoted by the arrow.

Hoxb8

Hoxd13

Hoxd7

100%

Hoxa1

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Oscillating expression of which signalling pathway genes plays a role in somite formation from presomitic mesoderm?

Duck embryos develop webbed feet while chicken embryos do not. Developmentally, what is the likely basis of duck's webbed feet?

Elevated SHH expression.

Reduced BMP expression.

67%

Enhanced BMP expression.

33%

Loss of FGF expression.

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Mutations in the Sox9 gene independently affect both cartilage and testis development. This is a an example of what type of developmental phenomenon?

Functional redundancy.

Mosaic polyphenism.

100%

Relational pleiotropy.

Mosaic pleiotropy.

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The schematic below shows the forelimb bud of a mouse embryo.