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DEV3011 - Experimental developmental biology and disease modelling - S1 2026
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What organising centre in the chicken embryo is the functional equivalent of the embryonic node in mouse?
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You cross a Slugh-LacZ/+ (heterozygous) male with a Slugh-LacZ/+ (heterozygous) female mouse and carry out β-galactosidase staining in E9.5 embryos. What would you typically expect to observe?
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What is the functional significance of the grey crescent in many amphibian embryos?
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A Drosophila larva has a loss-of-function mutation in the pair-rule gene, even-skipped. What the most likely outcome?
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Inducible knockout mouse models permit temporal control over the induction of specific gene knockouts. Tamoxifen is commonly used to induce Cre-mediated recombination in mouse models. Which of the following is a component of this system?
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An Honours student plans to over-express Fgf10 specifically in the heart of mouse embryos. What is needed for this experiment?
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You use Flp-FRT recombination in the eyes of Drosophila to investigate factors affecting growth and find that homozygous clones carrying a mutated (non-functional) gene “Tyrion” are smaller than wild-type clones. What would you conclude?
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In cells of the dorsal neural tube, BMP4 has just bound its Type II receptor. What is the first direct effect of this process?
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A researcher is using a dominant modifier screen to study eye size in Drosophila . The images below are of adult eyes with four different phenotypes in random order: wild type, sensitised, sensitised + enhancer mutant and sensitised + suppressor mutant.
Which image shows the sensitised + enhancer mutant eye?
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What is the name given to the process whereby one group of cells can influence the fate of another group of cells?
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