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DEV3011 - Experimental developmental biology and disease modelling - S1 2026

DEV3011 - Experimental developmental biology and disease modelling - S1 2026

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Consider the image below.

What type of protein is denoted by the black arrow?

Myosin.

Cadherin.

Integrin.

Intermediate filament.

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In the chicken embryo,

a researcher has removed the forelimb AER and replaced it was an FGF8-soaked bead.

Which result might

they expect?

Choose the best option below.

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Complete the following sentence.

The homeodomain _______________

is present in Hox genes

is localised to the cell membrane

encodes a trans-paralog

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The image below shows anterior boundaries of Hox gene expression in the mouse embryo.

Name the gene expression domain denoted by the arrow.

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A gene is being actively repressed. Under what conditions would this most typically occur?

H3K4 tri-methylation.

Removal of histones

Histone acetylation

DNA methylation

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Consider the family pedigree below, in which a monogenic autosomal congenital abnormality is denoted by shaded squares/circles. A= dominant allele, and a = recessive allele.

Based on the pedigree shown, what is the sex and genotype of the individual denoted by the arrow?

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Transplanting the isthmus to the neural tube at the level of the second branchial arch results in what effect?

Inhibition of Fgf8 expression in the isthmus and abnormal development of the midbrain

Inhibited growth of the upper and lower jaws due to abnormal proliferation

Abnormal migration of the neural crest from the neural tube into the first branchial arch

Inhibition of Hoxa2 expression and homeotic transformation of the second branchial arch

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What is the effect on a developing embryo of treatment

with a high dose of retinoids during early embryogenesis?

Similar effects to those produced by

insufficient retinoic acid signalling.

Impaired

somitogenesis but unaffected craniofacial and limb development.

Increased

production of retinoic acid synthesising enzymes.

Sustained

increase in retinoic acid signalling during development.

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The extension of the neural plate along the anterior-posterior axis requires what cellular changes?

Formation of polarised lamellipodia on the medial and lateral borders of the cells

Constriction of apical filaments of actin in the epithelium at defined hinge points

Elongation of individual cells along the anterior-posterior axis of the cells

Movement of individual cells in a lateral direction to expand the neural plate

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What is the function of the segmentation clock during somitogenesis?

It drives periodic somite formation.

It moves anteriorly due to axis elongation.

It generates an Fgf/Wnt gradient across the long axis.

It buds off the pre-somitic mesoderm to form a somite.

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