DEV3011 - Experimental developmental biology and disease modelling - S1 2026

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Consider the limb bud below, in which a chicken embryo has a gene mutation that blocks proper formation of the structure marked by X.

What is the first and most obvious defect that

would occur in the limb bud if tissue X failed to form?

Failed anterior-posterior patterning

❌

Disrupted proximal-distal patterning

✅

Two ventral surfaces

❌

Over-proliferation of the progress zone

❌

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The image below shows whole mount in situ hybridisation staining for mRNA expression in a mouse embryo.

 What is the most likely gene being examined here?

Bicoid

❌

Hoxa3

❌

Cdx2

❌

Hoxc13

✅

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The image below shows a spermatogonium that will give rise to four haploid gametes. Note the position of the labelled alleles.

What is the most likely result after meiosis to generate these four gametes?

Mutation of the b alleles

❌

Linkage equilibrium

❌

Loss of the A alleles

❌

Linkage disequilibrium

✅

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