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DEV3011 - Experimental developmental biology and disease modelling - S1 2026

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A mouse embryo has a mutation that disrupts specification of the sclerotome. What direct effect might this have?

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What is a feature of cadherins? Chose the correct answer below.

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In the chicken embryo,

a researcher has removed the forelimb bud mesenchyme from beneath the AER and

replaced it with non-limb mesenchyme. 

Which result might

they expect? 

Choose the best option below.

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What is the value of ATAC-seq in developmental biology?
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Consider the family pedigree below, in which a monogenic autosomal congenital abnormality is denoted by shaded squares/circles.

 Based on the pedigree shown, what term best describes the abnormality?
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What modification of the HTT gene would be needed to model Huntington’s disease in neuronal stem cells derived from an unaffected human?
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A gene in the mouse embryo is maternally imprinted. What does this mean?
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A gene is being actively expressed. Under what conditions would this most typically occur?
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What is the role of TGFβ3 in palate formation?
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What is the cellular basis of Treacher-Collins syndrome?
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