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DEV3011 - Experimental developmental biology and disease modelling - S1 2026

DEV3011 - Experimental developmental biology and disease modelling - S1 2026

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Treacher-Collins

syndrome features hypoplasia of facial bones

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A mouse embryo has a loss-of-function mutant in Sox10, which has impeded proper cranial neural crest migration. What would be the most likely result?

Hair loss over the head

Impaired forebrain formation

Failure of parietal bone formation in the skull

Deficient melanocytes

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Which of the following below is an example of polyphenism?

Mouse embryos with different genotypes have different coat colour

Insect species that lack a larval or pupal stage before adulthood

An allele is lethal when homozygous but the heterozygote is viable.

Turtle embryos with temperature-dependent sex determination

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"Intermediate levels of BMP are not sufficient to form the neural plate border". True or False?

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What is a feature of cadherins?

They interact with myosin filaments.

They do not span the cell membrane.

They bind calcium.

They drive cell motility.

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What is an adherens junction?

Adhesion between actin filaments in a cell

Linkage between actin bundles in neighbouring cells

An actin junction between the nucleus and cytoplasm

A place on a train station where chocolate is sold

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Consider the image

below of a section through the developing neural tube

If I conducted

in

situ

hybridisation on this neural tube, which of the following would I

see?

High SHH protein expression ventrally

High BMP mRNA ventrally

SHH mRNA expression throughout the tube

High BMP mRNA expression dorsally

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Consider the limb bud below, in which a chicken embryo has a gene mutation that blocks proper formation of the structure marked by X.

What is the first and most obvious defect that

would occur in the limb bud if tissue X failed to form?

Failed anterior-posterior patterning

Disrupted proximal-distal patterning

Two ventral surfaces

Over-proliferation of the progress zone

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What is the purpose of the “Brainbow” technique?

Deletion of a subset of neuronal cells in the brain

Lineage tracing of individual cells and their progeny

Conditional expression of one fluorescent tag in all brain cells

Over-expression of three different colours in all cells

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Complete the following : Lamellipodia and filopodia are extended or retracted via changes to _______ ?

chocolate intake

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