NMDA receptor antagonist, memantine

β-secretase inhibitor, rosiglitazone

monoclonal antibody for soluble Aβ, solanezumab

reversible cholinesterase inhibitor, donepezil

The assertion and reason are true statements AND the reason is the correct explanation of the assertion.

The assertion and reason are true statements but the reason is NOT a correct explanation of the assertion.

Both assertion AND reason are false statements.

The assertion is true BUT the reason is a false statement.

Benzodiazepines are appropriate for the long-term management of epilepsy.

Gabapentin activates GABA_A receptors following binding at the orthosteric site.

Inhibiting GABA transaminase will result in increased intracellular stores of GABA.

Na⁺ channel blockers used to treat epilepsy preferentially bind to the channel in its open state.

Some have been withdrawn due to adverse effects.

The benefits of these drugs persist even when treatment stops.

These drugs are effective at reversing cognitive decline.

These drugs do not differentiate between AChE and BChE.

CT scan

nerve conduction test

MRI with contrast

lumbar puncture

a diuretic, eg. mannitol

mechanical thrombectomy

an NMDA receptor antagonist, eg. memantine

recombinant tissue plasminogen activator (rt-PA)

Neuronal death occurs in the brainstem and spinal cord, but not the brain.

It is associated with mutation of superoxide dismutase 1 (SOD1).

The primary source of reactive oxygen species (ROS) in ALS is monoamine oxidase B.

Approximately 80-90% of cases are inherited.

arises from the progression of relapse-remitting MS.

is the most severe form of MS.

follows from primary progressive MS.

is characterised by periods of no disease activity.

is an immunomodulator that destroys all B and T lymphocytes.

is a monoclonal antibody that binds to CD20 and promotes B lymphocyte apoptosis.

should only be used in combination with plasmapheresis.

use should be avoided in patients with JC virus.

are a substrate for dopa decarboxylase in the periphery.

can be associated with hypertension, due to their peripheral effects.

are associated with little dyskinesia, but can be associated with the development of impulsive behaviours.

need to be administered with COMT inhibitors, in order to preserve their levels in the CNS.