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PHA3032 - Neuro and endocrine pharmacology - S2 2026

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Which one of the following statements about the anxiolytics / hypnotics below is CORRECT?

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Below is a pair of statements - an ASSERTION (statement 1) and REASON (statement 2).

Haloperidol is less likely to relieve the negative symptoms associated with schizophrenia

BECAUSE

Haloperidol does not antagonise D1 receptors in the pre-frontal cortex 

Which of the following options regarding these statements is CORRECT?

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The makeup of alpha subunits in the GABAa receptor can influence benzodiazepine action.

A loss-of-function mutation in the alpha1 subunit of the GABAa receptor site is MOST LIKELY to have which of the following effects on a benzodiazepine?

Select all that apply.

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Which one of the following statements relating to agents interacting with the GABAa receptor is CORRECT?

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Reversible monoamine oxidase (MAO) type A inhibitors:

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Which one of the following statements about anti-psychotic drugs is CORRECT?

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First generation anti-psychotic drugs such as haloperidol tend to be less effective at addressing the negative symptoms of schizophrenia.

This is BEST explained by their relative lack of effect in which one of the following brain regions / pathways?

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Tricyclic anti-depressants can be associated with abnormalities in cardiac function. 

This is MOST LIKELY because these drugs:

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1. Disulfiram is effective in helping with alcohol addiction

BECAUSE

2. Disulfiram antagonises the development of negatively reinforced addiction

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“Dull” pain:

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