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DEV3011 - Experimental developmental biology and disease modelling - S1 2026

DEV3011 - Experimental developmental biology and disease modelling - S1 2026

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Which description below characterises ENU mutagenesis in the mouse?

It is an example of targeted mutagenesis

Dominant mutations are only revealed in G3 offspring

G1 progeny are examined during a dominant screen

67%

Male mice in each generation are treated with a mutagen

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A cell carries a mutation that renders MAP kinases inactive. What would be the result?

Activation of Fgf responsive genes

100%

Failure of Receptor Tyrosine Kinase (RTK) signaling

No dimerisation of RTK receptors

Activation of Receptor Tyrosine Kinase (RTK) signaling

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The image below shows cDNAs on an agarose gel.

The gel shows the results of what type of experiment?

A Drosophila larva has a loss-of-function mutation in the segment polarity gene, engrailed, that prevents the encoded protein binding to its targets. What the most likely outcome?

Up-regulation of gap gene expression

Segmentation of the larva into compartments

50%

Disruption of homeotic gene expression

50%

Down-regulation of nanos gene expression

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A cell carries a mutation that causes constant activation of Ras-GTP. What would be the result?

Activation of Fgf responsive genes

50%

No dimerisation of RTK receptors

Inactivation of Receptor Tyrosine Kinase (RTK) signaling

No binding of Fgf to its receptor

50%

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You are a researcher investigating signalling pathways in neurons. You have detected the presence of Gli activator protein in the nucleus of the neuronal cells you are studying.

What does this indicate?

Smoothened is activated

Wnt proteins are present on the cell

Hedgehog responsive genes are inhibited

50%

Patched receptor is activated

50%

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The image below shows tissue section mRNA in situ hybridisation for the Plxnb1

gene in a mouse embryo.

What was required to yield specific staining in this tissue section?

Hydrogen peroxidase enzyme.

A fluorescent secondary antibody.

An anti- digoxygenin antibody.

A Plxnb1 antibody.

100%

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You cross a Slugh wild type male with a Slugh-LacZ/+ (heterozygous) female mouse and carry out beta -galactosidase staining in E9.5 embryos. What would you typically expect to observe?

Blue staining reaction in 50% of the embryos.

100%

The LacZ gene in all embryos.

Blue staining reaction in all embryos.

Blue staining reaction in 75% of the embryos.

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A researcher is using a dominant modifier screen to study eye size in Drosophila

. The images below are of adult eyes with four different phenotypes in random order: wild type, sensitised, sensitised + enhancer mutant and sensitised + suppressor mutant.